Since 2020, aggregated from related topics
Organic anion transporting polypeptides (OATPs) are a group of membrane transport proteins that play a crucial role in the uptake of various endogenous compounds, drugs, and environmental toxins into cells. OATPs are primarily expressed in the liver, kidney, intestine, and brain, where they facilitate the transport of a wide range of substrates across cell membranes. Research in the field of OATPs focuses on understanding the structure and function of these transporters, as well as their role in drug pharmacokinetics, drug-drug interactions, and drug toxicity. Studies have also investigated the regulation of OATP expression and activity, as well as their potential as targets for drug delivery and therapeutic intervention. Overall, research in the area of organic anion transporting polypeptides aims to enhance our understanding of the mechanisms underlying drug transport and metabolism, and to identify novel strategies for improving the efficacy and safety of pharmacotherapy.